Managing leg ulcer pain in sickle cell disease

Managing acute and chronic pain in sickle cell disease.

Acute painful episodes among patients with sickle cell disease may occur in any body part or several sites simultaneously. The reasons for inadequate pain relief for this patient group are complex. Prompt, accurate pain assessment is the cornerstone of effective pain management and a comprehensive, multidisciplinary team strategy is essential, particularly for managing patients with frequent ac...

Leg ulcers in sickle cell disease.

Sickle cell disease is a single amino acid molecular disorder of hemoglobin leading to its pathological polymerization, red cell rigidity that causes poor microvascular blood flow, with consequent tissue ischemia and infarction. The manifestations of this disease are protean.Among them, leg ulcers represent a particularly disabling and chronic complication, often associated with a more severe c...

Duodenal ulcer in sickle cell disease.

Intracardiac Thrombosis in Sickle Cell Disease

In patients with sickle cell disease, thrombotic microangiopathy is a rare complication. Also in sickle cell disease, intracardiac thrombus formation without structural heart diseases or atrial arrhythmias is a rare phenomenon. We herein describe a 22-year-old woman, who was a known case of sickle cell-βthalassemia, had a history of recent missed abortion, and was admitted with a vaso-occlusive...

Postural vasoconstriction and leg ulceration in homozygous sickle cell disease.

1. Chronic leg ulceration is a major cause of morbidity in patients with homozygous sickle cell disease; the ulcers commonly resolve on bed rest. We have therefore compared the cutaneous vascular response to dependency in three groups of eight patients with sickle cell disease (those with an active ulcer, with an ulcer scar and with no history of ulceration) and in eight subjects with normal ha...